This paper investigates spatial computing, which is a pathological transformational modern technology that integrates the physical and digital realms and has the potential to revolutionize pathology healthcare. Pathology as a medical specialist plays a crucial role in patient care by providing essential information for diagnosis, treatment planning, and disease monitoring. It studies and diagnoses diseases by examining tissues, organs, bodily fluids, and cells. Pathology is a broad field with three main branches: Anatomic pathology, Clinical pathology, and Molecular pathology. This study investigates the possibilities of spatial computing in radiography and clinical pathology with emphasis on diagnosis accuracy, medical education, workflow efficiency, and the outcomes in the patients. Augmented Reality (AR) medical devices guide pathologists in real-time during diagnostics procedures. The digital reproduction of tissue samples to allow pathologists to examine specimens in three dimensions is a significant utilization of spatial computing in virtual microscopy. This process allows remote collaboration between pathologists and laboratories, provides health informatics as seen in electronic health records (EHRs), improves diagnosis, and presents a platform with learning experiences in the medical field. Patients can interact with three-dimensional simulations of their anatomy, which helps them make more educated treatment decisions provided via the pathology findings and treatment alternatives in an immersive format. As this technology advances, its potential to transform pathology practice and improve patient care remains high. This review describes technological perspectives and discusses the statistical methods, clinical applications, potential obstacles, and directions of spatial computing in clinical pathology.
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